Erectile dysfunction strongly predictive of atherosclerotic cardiovascular events

January 01, 0001

Erectile dysfunction strongly predictive of atherosclerotic cardiovascular events

In spite of the mounting interest in the nexus between erectile dysfunction (ED) and cardiovascular (CV) diseases, there is little published information on the role of ED as a predictor for subsequent CV events. This study by researchers from Australia aimed to investigate the role of ED as a predictor for atherosclerotic CV events subsequent to the manifestation of ED. The investigation involved the retrospective study of data on a cohort of 1,660 men with ED linked to hospital morbidity data and death registrations. By using the linked data, the incidence rates of atherosclerotic CV events subsequent to the manifestation of ED were estimated in men with ED and no atherosclerotic CV disease reported prior to the manifestation of ED. The risk of subsequent atherosclerotic CV events in men with ED was assessed by comparing these incidence rates with those in the general male population.

On the basis of hospital admissions and death registrations, men with ED had a statistically significantly higher incidence of atherosclerotic CV events (risk ratio 2.2). There were significantly increased incidence rate ratios in all age groups younger than 70 years, with a statistically highly significant downward trend with increase of age across these age groups. Younger age at first manifestation of ED, cigarette smoking, presence of comorbidities and socioeconomic disadvantage were all associated with higher hazard ratios for subsequent atherosclerotic CV events.

The researchers concluded: "The findings show that ED is not only significantly associated with but is also strongly predictive of subsequent atherosclerotic CV events. This is even more striking when ED presents at a younger age."

This is an interesting study as we are told ED is underreported and is frequently not recorded in hospital notes. Working with this cohort gives much more information.

For the full abstract, click here.

Journal of Sexual Medicine 7(1):192 - 202, published online 13 Nov 2009 (doi: 10.1111/j.1743-6109.2009.01576.x) © 2010 International Society for Sexual Medicine
Erectile Dysfunction as a Predictor for Subsequent Atherosclerotic Cardiovascular Events: Findings from a Linked-Data Study. Kew-Kim Chew, Judith Finn, Bronwyn Stuckey et al. Correspondence to Kew-Kim Chew: [email protected]

Category: K. Circulatory, Y. Male Genital System. Keywords: atherosclerotic cardiovascular events, endothelial dysfunction, erectile dysfunction, linked data study
Synopsis edited by Dr Stephen Wilkinson, Melbourne, Australia. Posted on Global Family Doctor 4 February 2010

Pearls are an independent product of the Cochrane primary care group and are meant for educational use and not to guide clinical care.