No benefit of partially hydrolyzed whey infant formula for allergy

January 01, 0001

No benefit of partially hydrolyzed whey infant formula for allergy

Partially hydrolyzed whey formula (pHWF) has been recommended for infants with a family history of allergic disease at the cessation of exclusive breast-feeding to promote oral tolerance and prevent allergic diseases. The aim of this study by researchers from Australia was to determine whether feeding infants pHWF reduces their risk of allergic disease. A single-blind (participant) randomized controlled trial was conducted to compare allergic outcomes between infants fed a conventional cow’s milk formula, a pHWF, or a soy formula. Before birth, 620 infants with a family history of allergic disease were recruited and randomized to receive the allocated formula at cessation of breast-feeding. Skin prick tests to 6 common allergens (milk, egg, peanut, dust mite, rye grass, and cat dander) were performed at 6, 12, and 24 months. Follow- up was complete for 93% at 2 years and 80% at 6 or 7 years of age.

There was no evidence that infants allocated to the pHWF (odds ratio, 1.21) or the soy formula (odds ratio, 1.26) were at a lower risk of allergic manifestations in infancy compared with conventional formula. There was also no evidence of reduced risk of skin prick test reactivity or childhood allergic disease.

The researchers concluded: "Despite current dietary guidelines, we found no evidence to support recommending the use of pHWF at weaning for the prevention of allergic disease in high-risk infants."

Will this change guidelines or behaviour?

For the full abstract, click here.

Journal of Allergy and Clinical Immunology published online 22 June 2011 © 2011 American Academy of Allergy, Asthma & Immunology
Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: A randomized controlled trial. Adrian J. Lowe, Clifford S. Hosking FRACP, Catherine M. Bennett et al. Correspondence to David Hill: [email protected]

Category: B. Blood/Blood Forming Organs/Immune Mechanisms. Keywords: allergy prevention, infant formulas, partially hydrolyzed whey formula, conventional cow’s milk formulas, eczema, asthma, allergic rhinitis, randomized control trial, journal watch.
Synopsis edited by Dr Stephen Wilkinson, Melbourne, Australia. Posted on Global Family Doctor 8 July 2011

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