Tinidazole = metronidazole for the treatment of bacterial vaginosis

January 01, 0001

Tinidazole = metronidazole for the treatment of bacterial vaginosis

The purpose of this study by US authors was to compare the efficacy of 2 different doses of tinidazole with metronidazole for the treatment of bacterial vaginosis and to compare the side effects of the drugs. Women were assigned randomly to receive metronidazole 500 mg twice daily, tinidazole 500 mg twice daily, or tinidazole 1 g twice, all for 7 days. Follow- up visits were conducted at days 14 and 28.

They found: "Five hundred ninety-three women were enrolled. There were no significant differences between the treatment arms. Overall cure rates were 76.8% at 14 days and 64.5% at 1 month. Women who admitted to engaging in sexual intercourse during the study were significantly more likely to have bacterial vaginosis at the follow-up visit. There were no significant differences in adverse events across treatment arms."

The authors concluded: "There were no differences in cure rates between metronidazole and either of the tinidazole dosing regimens that were studied. In addition, there were no important differences in the side-effect profiles of metronidazole and tinidazole."

Tinidazole is another treatment option to consider for bacterial vaginosis.


For the full abstract, click here.

Am J Obstet Gynecol 204(3):211.e1-211.e6, March 2011 © 2011 to Mosby, Inc.
Tinidazole vs metronidazole for the treatment of bacterial vaginosis. Jane R. Schwebke, Renee A. Desmond. Correspondence to Dr. Schwebke: [email protected]

Category: X. Female Genital System, Breast. Keywords: bacterial vaginosis, tinidazole, metronidazole, randomized controlled trial, journal watch.
Synopsis edited by Dr Linda French, Toledo, Ohio. Posted on Global Family Doctor 3 May 2011

Pearls are an independent product of the Cochrane primary care group and are meant for educational use and not to guide clinical care.

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