Non-selective NSAID plus a PPI still increase GIT bleeding

January 01, 0001

Non-selective NSAID plus a PPI still increase GIT bleeding

Cyclo-oxygenase (COX)-2-selective non-steroidal anti- inflammatory drugs (NSAIDs) and non-selective NSAIDs plus a proton- pump inhibitor (PPI) have similar upper gastrointestinal outcomes, but risk of clinical outcomes across the entire gastrointestinal tract might be lower with selective drugs than with non-selective drugs. The researchers aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole. They undertook a 6- month, double-blind, randomised trial in patients with osteoarthritis or rheumatoid arthritis at increased gastrointestinal risk at 196 centres in 32 countries or territories. Patients tested negative for Helicobacter pylori and were aged 60 years and older or 18 years and older with previous gastroduodenal ulceration. They used a computer-generated randomisation schedule to assign patients in a 1:1 ratio to receive celecoxib 200 mg twice a day or diclofenac slow release 75 mg twice a day plus omeprazole 20 mg once a day. Patients and investigators were masked to treatment allocation. 4484 patients were randomly allocated to treatment (2238 celecoxib; 2246 diclofenac plus omeprazole).

Risk of clinical outcomes throughout the gastrointestinal tract was lower in patients treated with a COX-2-selective NSAID than in those receiving a non-selective NSAID plus a PPI.

The researchers concluded: "These findings should encourage review of approaches to reduce risk of NSAID treatment."

And yet these agents (although not the same ones as in the study) are used so liberally in children.

For the full abstract, click here.

The Lancet published online 17 June 2010
© Elsevier Ltd 2010
Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Francis KL Chan, Angel Lanas, James Scheiman et al. Correspondence to Prof Francis KL Chan: [email protected]

Category: D. Digestive Keywords: celecoxib, omeprazole, diclofenac, osteoarthritis, rheumatoid arthritis, randomized trial, journal watch.
Synopsis edited by Dr Stephen Wilkinson, Melbourne, Australia. Posted on Global Family Doctor 9 July 2010

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