Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis

January 01, 0001

Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis

The purpose of this study by US authors was to examine which maternal and neonatal complications are associated with polycystic ovary syndrome (PCOS) in pregnant women. The studies that were included compared pregnancy outcomes between women with PCOS and those without diagnosed PCOS. The primary outcomes included gestational diabetes mellitus, pregnancy-induced hypertension, and preeclampsia. Secondary outcomes included cesarean delivery rates, operative vaginal delivery rates, preterm delivery, small-for- gestational-age (SGA) infants and large-for-gestational-age infants.

They found: "We found that PCOS in pregnancy was associated with higher rates of gestational diabetes mellitus, pregnancy-induced hypertension, preeclampsia, preterm delivery, cesarean delivery, operative vaginal delivery, SGA, and large-for-gestational age. Only gestational diabetes mellitus, pregnancy-induced hypertension, preeclampsia, preterm delivery, and SGA infants were found to be statistically significant."

The authors concluded: "This metaanalysis confirms the higher association of pregnancy complications and PCOS compared with patients who do not have PCOS. Additionally, there may be a stronger association between PCOS and hypertensive disorders than has been shown previously."

Underlying insulin resistance may be a common denominator.


For the full abstract, click here.

Am J Obstet Gynecol 204(6):558.e1-558.e6, June 2011 © 2011 to Mosby, Inc.
Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis. Lucinda E. Kjerulff, Luis Sanchez-Ramos, Daniel Duffy. Correspondence to Dr. Kjerulff: [email protected]

Category: W. Pregnancy, Family Planning. Keywords: complication, gestational diabetes mellitus, polycystic ovary syndrome, journal watch.
Synopsis edited by Dr Linda French, Toledo, Ohio. Posted on Global Family Doctor 5 July 2011

Pearls are an independent product of the Cochrane primary care group and are meant for educational use and not to guide clinical care.

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